Male Factor

Sperm Production

Sperm Detection

Sperm Abnormalities
  • Testicular Causes
  • Pituitary Causes
  • Hypothalamic &
    CNS Causes

  • Varicocele
  • Antisperm Antibodies

Clinical Evaluation

Treatment Options

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Dr Eric Daiter is a nationally recognized expert in Reproductive Endocrinology and Infertility who has proudly served patients at his office in New Jersey for 20 years. If you have questions or you just want to find a caring infertility specialist, Dr Eric Daiter would be happy to help you (in the office or on the telephone). It is easy, just call us at 908 226 0250 to set up an appointment (leave a message with your name and number if we are unable to get to the phone and someone will call you back).


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The CNS-hypothalamic causes for abnormalities in sperm include:

(1) Structural lesions

Structural lesions that interfere with the transport of GnRH from the hypothalamus to the pituitary gland may result in FSH and LH concentrations in the low-normal range along with a low circulating testosterone concentration. As with women, these men should have radiologic imaging to specifically rule out an anatomic lesion.

(2) Kallmanís syndrome

This is an uncommon disorder (responsible for less than 1% of azoospermia) in which the GnRH neurons do not develop normally. The GnRH neurons are located near the olfactory neurons (used for the sense of smell) in early development, and the process that causes the GnRH neurons to fail to migrate to their usual eventual location also results in failure of migration of the olfactory neurons. The result is a lack of GnRH effect on the pituitary gland (hypogonadotropic hypogonadism) and anosmia (inability to smell). The infertility caused by this syndrome is treatable by replacement of gonadotropins or GnRH using available fertility medications.

(3) Substance abuse

Illicit drugs (cocaine, opioid compounds, marijuana) are thought to primarily affect the brainís ability to communicate properly with the testes and thereby are disruptive to spermatogenesis.

Available Case Reports:

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